Dissolution of a colloidal particle in an oscillatory flow

[Display omitted] •Reconstitution of freeze-dried protein therapeutics is challenging.•There is a great need of understanding and optimizing the process.•We present the relevant flow dynamics, mass transfer, and dissolution kinetics.•The figure demonstrates transient flow patterns around a passively...

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Bibliographic Details
Published in:International journal of heat and mass transfer 2017-04, Vol.107, p.489-499
Main Authors: Ye, Dezhuang, Bogner, Robin, Li, Ji-Qin, Fan, Tai-Hsi
Format: Article
Language:English
Subjects:
Aqueous solutions
Colloidal particle
Computational fluid dynamics
Dissolution
Dissolution kinetics
Fluid flow
Fluids
Kinetics
Low Reynolds number
Low Reynolds number flow
Mass transfer
Oscillatory flow
Pharmaceutical
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Summary:[Display omitted] •Reconstitution of freeze-dried protein therapeutics is challenging.•There is a great need of understanding and optimizing the process.•We present the relevant flow dynamics, mass transfer, and dissolution kinetics.•The figure demonstrates transient flow patterns around a passively moving colloid. Understanding dissolution kinetics of a colloidal particle in an aqueous solution is of great importance in many pharmaceutical and biochemical applications. We present theoretical analysis of low Reynolds number flow dynamics and mass transfer of a dissolving spherical particle in a unidirectional oscillatory flow field. The coupling of fluid flow and passive motion of the particle are solved analytically, and the transient mass transfer associated with the oscillation of the particle is computed numerically. The flow patterns, basic characteristics of mass transport, and the simplified long-time dissolution process under various saturation concentrations and relative flow conditions are discussed in details.
ISSN:0017-9310
1879-2189
DOI:10.1016/j.ijheatmasstransfer.2016.11.066