Nanosized Minicells Generated by Lactic Acid Bacteria for Drug Delivery

Nanotechnology has the ability to target specific areas of the body, controlling the drug release and significantly increasing the bioavailability of active compounds. Organic and inorganic nanoparticles have been developed for drug delivery systems. Many delivery systems are through clinical stages...

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Bibliographic Details
Published in:Journal of nanomaterials 2017-01, Vol.2017 (2017), p.1-10
Main Authors: Nguyen, Huu Ngoc, Nguyen Hoang Khue, Tu, Romero Jovel, Santa
Format: Article
Language:English
Subjects:
Acids
Active control
Bacteria
Bioavailability
Biodegradability
Biodegradation
Biosynthesis
Cancer therapies
Cell division
Chemical compounds
Clinical trials
Cytotoxicity
Drug delivery systems
Drug resistance
Epidermal growth factor
Immunoglobulins
Immunology
Lactic acid
Ligands
Medical research
Microorganisms
Nanomaterials
Nanoparticles
Nanotechnology
Pharmacology
Probiotics
Reagents
Safety
Tumors
Vaccines
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Summary:Nanotechnology has the ability to target specific areas of the body, controlling the drug release and significantly increasing the bioavailability of active compounds. Organic and inorganic nanoparticles have been developed for drug delivery systems. Many delivery systems are through clinical stages for development and market. Minicell, a nanosized cell generated by bacteria, is a potential particle for drug delivery because of its size, safety, and biodegradability. Minicells produced by bacteria could drive therapeutic agents against cancer, microbial infection, and other diseases by targeting. In addition, minicells generated by lactic acid bacteria being probiotics are more interesting than others because of their benefits like safety, immunological improvement, and biodegradation. This review aims to highlight the stages of development of nanoparticle for drug delivery and discuss their advantages and limitations to clarify minicells as a new opportunity for the development of potential nanoparticle for drug delivery.
ISSN:1687-4110
1687-4129
DOI:10.1155/2017/6847297