Frontispiece: Bicyclic Peptides as Next‐Generation Therapeutics

Greater conformational rigidity and metabolic stability than linear and monocyclic peptides can be found in bicyclic peptide which are capable of binding to challenging drug targets with antibody‐like affinity and specificity. Powerful combinatorial library technologies have recently been developed...

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Bibliographic Details
Published in:Chemistry : a European journal 2017-09, Vol.23 (52), p.n/a
Main Authors: Rhodes, Curran A., Pei, Dehua
Format: Article
Language:English
Subjects:
Chemistry
click chemistry
Combinatorial analysis
combinatorial chemistry
Enzymes
Libraries
Peptide libraries
Peptides
phage display
Protein interaction
protein–protein interactions
Receptors
Rigidity
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Summary:Greater conformational rigidity and metabolic stability than linear and monocyclic peptides can be found in bicyclic peptide which are capable of binding to challenging drug targets with antibody‐like affinity and specificity. Powerful combinatorial library technologies have recently been developed to rapidly synthesize and screen large bicyclic peptide libraries for ligands against enzymes, receptors, and protein–protein interaction targets. For more details, see the Minireview by D. Pei and C. A. Rhodes on page 12690 ff.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201785262