Four new iridoid glucosides containing the furan ring from the fruit of Cornus officinalis

Four new and rare iridoid glucosides, cornusfuroside A–D (1–4), containing the furan ring were identified from water extract of the fruit of Cornus officinalis. These new chemical structures were determined through extensive spectroscopic analysis, including 1D and 2D NMR, IR, HRESIMS, experimental...

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Bibliographic Details
Published in:Fitoterapia 2017-07, Vol.120, p.136-141
Main Authors: He, Jun, Ye, Xian-Sheng, Wang, Xiao-Xue, Yang, Ya-Nan, Zhang, Pei-Cheng, Ma, Bing-Zhi, Zhang, Wei-Ku, Xu, Jie-Kun
Format: Article
Language:English
Subjects:
Circular dichroism
Cornus officinalis
Cornusfuroside A–D
Dichroism
Extraction processes
Fruits
Furan ring
Glucose
Glucosides
Infrared radiation
Neuroprotection
Neuroprotective effect
NMR
Nuclear magnetic resonance
Sugar
Two dimensional analysis
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Summary:Four new and rare iridoid glucosides, cornusfuroside A–D (1–4), containing the furan ring were identified from water extract of the fruit of Cornus officinalis. These new chemical structures were determined through extensive spectroscopic analysis, including 1D and 2D NMR, IR, HRESIMS, experimental and calculated electronic circular dichroism (ECD). Notably, this study is the first report on the isolation of four iridoid glucoside structures with acetal functions in the sugar moiety. The neuroprotective effects of these compounds were also evaluated in vitro. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2017.06.003