Production, applications and status of zirconium-89 immunoPET agents

Zirconium-89 has attracted huge interests and is used in tracing and quantification of slow biological processes and labeling of long half-live biomolecules such as monoclonal antibodies for pharmacokinetic studies and clinical trials. In this review, a concise introduction to targetry, irradiation...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2017-10, Vol.314 (1), p.7-21
Main Authors: Jalilian, Amir R., Osso, Joao Alberto
Format: Article
Language:English
Subjects:
Biological activity
Biomolecules
Chemistry
Chemistry and Materials Science
Clinical trials
Conjugation
Diagnostic Radiology
Hadrons
Heavy Ions
Inorganic Chemistry
Medical research
Monoclonal antibodies
Nuclear Chemistry
Nuclear Physics
Nuclear reactors
Pharmacology
Physical Chemistry
Positron emission tomography
Radiation (Physics)
Zirconium
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Summary:Zirconium-89 has attracted huge interests and is used in tracing and quantification of slow biological processes and labeling of long half-live biomolecules such as monoclonal antibodies for pharmacokinetic studies and clinical trials. In this review, a concise introduction to targetry, irradiation data, separation and coordination chemistry of zirconium-89 has been presented. A detailed overreviwew on bi-functional ligands conjugation and 89 Zr radiolabeling been addressed. The latest status of preclinical as well as clinical trials using 89 Zr radioimmunomolecules in various human diseases has been presented since 2012.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-017-5358-z