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Production, applications and status of zirconium-89 immunoPET agents
Zirconium-89 has attracted huge interests and is used in tracing and quantification of slow biological processes and labeling of long half-live biomolecules such as monoclonal antibodies for pharmacokinetic studies and clinical trials. In this review, a concise introduction to targetry, irradiation...
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| Published in: | Journal of radioanalytical and nuclear chemistry 2017-10, Vol.314 (1), p.7-21 |
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| Main Authors: | , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c383t-2ad607de4fb5aa1a0fbdf6f4d6e6604fafc4ec32eca62182e9c6847325f9c2ef3 |
| container_end_page | 21 |
| container_issue | 1 |
| container_start_page | 7 |
| container_title | Journal of radioanalytical and nuclear chemistry |
| container_volume | 314 |
| creator | Jalilian, Amir R. Osso, Joao Alberto |
| description | Zirconium-89 has attracted huge interests and is used in tracing and quantification of slow biological processes and labeling of long half-live biomolecules such as monoclonal antibodies for pharmacokinetic studies and clinical trials. In this review, a concise introduction to targetry, irradiation data, separation and coordination chemistry of zirconium-89 has been presented. A detailed overreviwew on bi-functional ligands conjugation and
89
Zr radiolabeling been addressed. The latest status of preclinical as well as clinical trials using
89
Zr radioimmunomolecules in various human diseases has been presented since 2012. |
| doi_str_mv | 10.1007/s10967-017-5358-z |
| format | article |
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89
Zr radiolabeling been addressed. The latest status of preclinical as well as clinical trials using
89
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89
Zr radiolabeling been addressed. The latest status of preclinical as well as clinical trials using
89
Zr radioimmunomolecules in various human diseases has been presented since 2012.</description><subject>Biological activity</subject><subject>Biomolecules</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Clinical trials</subject><subject>Conjugation</subject><subject>Diagnostic Radiology</subject><subject>Hadrons</subject><subject>Heavy Ions</subject><subject>Inorganic Chemistry</subject><subject>Medical research</subject><subject>Monoclonal antibodies</subject><subject>Nuclear Chemistry</subject><subject>Nuclear Physics</subject><subject>Nuclear reactors</subject><subject>Pharmacology</subject><subject>Physical Chemistry</subject><subject>Positron emission tomography</subject><subject>Radiation (Physics)</subject><subject>Zirconium</subject><issn>0236-5731</issn><issn>1588-2780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kctKAzEUhoMoWKsP4G7Aram5zCSZZalXKNhFXYc0k5SUTjImMwv79KaMoIISOOEc_u9c-AG4xmiGEeJ3CaOacYgwhxWtBDycgAmuhICEC3QKJohQBitO8Tm4SGmHEKqFoBNwv4qhGXTvgr8tVNftnVbHJBXKN0XqVT-kItji4KIO3g0tFHXh2nbwYfWwLtTW-D5dgjOr9slcff1T8Pb4sF48w-Xr08tivoSaCtpDohqGeGNKu6mUwgrZTWOZLRtmGEOlVVaXRlNitGIEC2JqzUTJKalsrYmxdApuxr5dDO-DSb3chSH6PFLiusSc1iXj36qt2hvpvA19VLp1Sct5hVg-PMesmv2hyq8xrcunGuty_ReAR0DHkFI0VnbRtSp-SIzk0QM5eiCzB_LogTxkhoxMylq_NfHHwv9Cn5UZiUU</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Jalilian, Amir R.</creator><creator>Osso, Joao Alberto</creator><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20171001</creationdate><title>Production, applications and status of zirconium-89 immunoPET agents</title><author>Jalilian, Amir R. ; Osso, Joao Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-2ad607de4fb5aa1a0fbdf6f4d6e6604fafc4ec32eca62182e9c6847325f9c2ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biological activity</topic><topic>Biomolecules</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Clinical trials</topic><topic>Conjugation</topic><topic>Diagnostic Radiology</topic><topic>Hadrons</topic><topic>Heavy Ions</topic><topic>Inorganic Chemistry</topic><topic>Medical research</topic><topic>Monoclonal antibodies</topic><topic>Nuclear Chemistry</topic><topic>Nuclear Physics</topic><topic>Nuclear reactors</topic><topic>Pharmacology</topic><topic>Physical Chemistry</topic><topic>Positron emission tomography</topic><topic>Radiation (Physics)</topic><topic>Zirconium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jalilian, Amir R.</creatorcontrib><creatorcontrib>Osso, Joao Alberto</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jalilian, Amir R.</au><au>Osso, Joao Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Production, applications and status of zirconium-89 immunoPET agents</atitle><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle><stitle>J Radioanal Nucl Chem</stitle><date>2017-10-01</date><risdate>2017</risdate><volume>314</volume><issue>1</issue><spage>7</spage><epage>21</epage><pages>7-21</pages><issn>0236-5731</issn><eissn>1588-2780</eissn><abstract>Zirconium-89 has attracted huge interests and is used in tracing and quantification of slow biological processes and labeling of long half-live biomolecules such as monoclonal antibodies for pharmacokinetic studies and clinical trials. In this review, a concise introduction to targetry, irradiation data, separation and coordination chemistry of zirconium-89 has been presented. A detailed overreviwew on bi-functional ligands conjugation and
89
Zr radiolabeling been addressed. The latest status of preclinical as well as clinical trials using
89
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| identifier | ISSN: 0236-5731 |
| ispartof | Journal of radioanalytical and nuclear chemistry, 2017-10, Vol.314 (1), p.7-21 |
| issn | 0236-5731 1588-2780 |
| language | eng |
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| source | Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List |
| subjects | Biological activity Biomolecules Chemistry Chemistry and Materials Science Clinical trials Conjugation Diagnostic Radiology Hadrons Heavy Ions Inorganic Chemistry Medical research Monoclonal antibodies Nuclear Chemistry Nuclear Physics Nuclear reactors Pharmacology Physical Chemistry Positron emission tomography Radiation (Physics) Zirconium |
| title | Production, applications and status of zirconium-89 immunoPET agents |
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