Acid‐Labile Acyclic Cucurbituril Molecular Containers for Controlled Release

Stimuli‐responsive molecular containers are of great importance for controlled drug delivery and other biomedical applications. A new type of acid labile acyclic cucurbit[n]uril (CB[n]) molecular containers is presented that can degrade and release the encapsulated cargo at accelerated rates under m...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2017-10, Vol.56 (41), p.12614-12618
Main Authors: Dake Mao, Liang, Yajun, Liu, Yamin, Zhou, Xianhao, Ma, Jiaqi, Jiang, Biao, Liu, Jia, Ma, Da
Format: Article
Language:English
Subjects:
Acids
Biomedical materials
Cell culture
Containers
Controlled release
Drug delivery
Drug delivery systems
pH effects
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Summary:Stimuli‐responsive molecular containers are of great importance for controlled drug delivery and other biomedical applications. A new type of acid labile acyclic cucurbit[n]uril (CB[n]) molecular containers is presented that can degrade and release the encapsulated cargo at accelerated rates under mildly acidic conditions (pH 5.5–6.5). These containers retain the excellent recognition properties of CB[n]‐type hosts. A cell culture study demonstrated that the cellular uptake of cargos could be fine‐tuned by complexation with different containers. The release and cell uptake of cargo dye was promoted by acidic pH.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201707164