Hepatoprotective activity of the hydro-alcoholic extract of the Gracilaria edulis (Gmelin)

Silymarin (50mg/kg, p.o) Cirrhosis was induced in Wistar rats by chronic exposure to CCl4 vapours in an inhalation chamber and phenobarbitone in drinking water (500mg/l) for a period of 4 weeks(20min/ twice weekly) for as described by Mclean et.al., After 4 weeks of CCl4 treatment animals were divid...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2017, Vol.10 (6), p.1647
Main Authors: Sikdar, Pranabesh, Ramana, M. Venkata
Format: Article
Language:English
Subjects:
Algae
Animals
Antioxidants
Carotenoids
Drug dosages
Hematology
Hepatitis
Homeostasis
Liver cirrhosis
Liver diseases
Natural products
Physiology
Rodents
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Summary:Silymarin (50mg/kg, p.o) Cirrhosis was induced in Wistar rats by chronic exposure to CCl4 vapours in an inhalation chamber and phenobarbitone in drinking water (500mg/l) for a period of 4 weeks(20min/ twice weekly) for as described by Mclean et.al., After 4 weeks of CCl4 treatment animals were divided in to 6 groups of 6 animals each. Estimation of liver Glutathione (GSH), Superoxide dismutase (SOD), Catalase and glutathione peroxidase (GPx) levels: GSH (Cayman-703102), SOD (Cayman-706002), catalase (Cayman-707002) and GPx (Cayman-703102) activities/levels were estimated using Cayman assay kits (cayman chemical company, Ann Arbor, USA) Estimation of liver peroxide levels: The serum biochemistry (ASAT, ALAT, ALP and TP), liver antioxidant status (SOD, Catalase, GSH, GPx, and lipid peroxide levels) and liver histopathology analysis revealed a varying degree of hepatoprotection by the test item. [...]the above results clearly demonstrate that the test item has significant hepatoprotective activity.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2017.00290.6