Comparative In vitro antidiabetic and antioxidant activity of Pulicaria wightinia, Curcuma inodora, Derris scandens leaf extracts

• Published in: Research journal of pharmacy and technology 2017, Vol.10 (6), p.1615
• Main Authors: Vidyasabbani, Alluri, Ramesh, Satla, Shobharani
• Format: Article
• Language: English
• Subjects: Antidiabetics; Antioxidants; Diabetes; Enzymes; Glucose; Herbal medicine; Methods; Oxidative stress; Plant sciences; Taxonomy
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2017.00284.0

[...]for many plant extracts, there is no clear understanding of the mechanism of action. [...]natural a-glucosidase inhibitors from plant sources offer an attractive strategy for the control of postprandial hyperglycemias. [...]glucose transport occurs only if the intracellular glucose is effectively reduced (utilized). The data obtained clearly suggests that the plant extracts are capable of effectively enhancing glucose uptake which in turn suggests that it is capable of enhancing effective glucose utilization thereby controlling blood glucose level Antioxidant assay by DPPH scavenging method: The inhibition of alpha glycosidase enzyme and glucose uptake by yeast cells by the leaves of three plants in the present study provides a strong biochemical basis for the management of diabetes via the control of glucose absorption and increase of glucose uptake which in turn regulate blood glucose levels. [...]the results obtained from the present study are useful in determining the mechanism of action of plant extracts for antidiabetic activity.