A preliminary study into the efficacy of antibiotic doped niobium oxide coatings on 316L prepared by incipient wetness impregnation and sol-gel synthesis

•Crack free, spatially homogeneous niobium oxide coatings were realized via sol-gel.•Erythromycin in varying concentration was incorporated by different processing routes.•The release of drug from coatings and performance against S. aureus was determined. Erythromycin was incorporated into niobium o...

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Bibliographic Details
Published in:Materials letters 2017-03, Vol.190, p.150-153
Main Authors: Pradhan, D., Wren, A.W., Mellott, N.P.
Format: Article
Language:English
Subjects:
Antibiotics
Austenitic stainless steels
Biomaterials
Biomedical materials
Ceramics
Coating effects
Erythromycin
Functional
Materials science
Moisture content
Niobium
Oxide coatings
Sol-gel preparation
Sol-gel processes
Stainless steel
Surfaces
Thin films
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Summary:•Crack free, spatially homogeneous niobium oxide coatings were realized via sol-gel.•Erythromycin in varying concentration was incorporated by different processing routes.•The release of drug from coatings and performance against S. aureus was determined. Erythromycin was incorporated into niobium oxide coatings on stainless steel via advanced sol-gel processing. The effects of drug incorporation on the coatings were evaluated via SEM imaging. The release of erythromycin was measured and short term antibacterial properties were analyzed for 3 and 24h. Further, the adhesion of S. aureus on the drug containing surfaces were also observed. A comparative study for release and antibacterial properties of erythromycin containing niobium oxide coatings was made based on two different processing routes, variation in drug concentration and immersion time.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2017.01.001