Antihypertensive Activities of Peptides Derived from Porcine Skeletal Muscle Myosin in Spontaneously Hypertensive Rats

Antihypertensive activities derived from porcine skeletal muscle proteins were investigated. Thermolysin hydrolysates of porcine muscle water‐insoluble proteins demonstrated antihypertensive activities in spontaneously hypertensive rats when administrated in single oral doses. Hydrolysates of porcin...

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Bibliographic Details
Published in:Journal of food science 2002-01, Vol.67 (1), p.434-437
Main Authors: Nakashima, Y., Arihara, K., Sasaki, A., Mio, H., Ishikawa, S., Itoh, M.
Format: Article
Language:English
Subjects:
Animal, plant, fungal and microbial proteins, edible seaweeds and food yeasts
antihypertensive activity
Biological and medical sciences
Food industries
Food science
Fundamental and applied biological sciences. Psychology
General pharmacology
Hypertension
Medical sciences
myosin
peptide
Peptides
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
porcine skeletal muscle
Pork
Proteins
Rodents
spontaneously hypertensive rat
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Summary:Antihypertensive activities derived from porcine skeletal muscle proteins were investigated. Thermolysin hydrolysates of porcine muscle water‐insoluble proteins demonstrated antihypertensive activities in spontaneously hypertensive rats when administrated in single oral doses. Hydrolysates of porcine myosin and peptides (Met‐Asn‐Pro‐Pro‐Lys, Ile‐Thr‐Thr‐Asn‐Pro, Met‐Asn‐Pro, Pro‐Pro‐Lys) with parts of the sequence of myosin showed antihypertensive activities. This is the first report of antihypertensive activities of peptides derived from muscle proteins of domestic animals. The hydrolysates of porcine muscle protein and their corresponding bioactive peptides might be utilized for physiologically functional foods.
ISSN:0022-1147
1750-3841
DOI:10.1111/j.1365-2621.2002.tb11424.x