An efficient and convenient aldol addition of acyldiazomethane with aldehydes promoted by MgI 2 etherate

The aldol addition of acyldiazomethane with aromatic aldehydes, vinyl aldehyde and aliphatic aldehydes was carried out efficiently in the presence of MgI 2 etherate and iPr 2 EtN (DIPEA) using untreated reagent-grade CH 2 Cl 2 under atmospheric conditions in good to excellent yields. Iodide counteri...

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Bibliographic Details
Published in:Main group metal chemistry 2017-08, Vol.40 (3-4), p.87
Main Authors: Xie, Xiaoqiang, Qi, Weipeng, Sun, Xinzhe, Zhang, Xingxian
Format: Article
Language:English
Subjects:
Aldehydes
Aliphatic compounds
Online Access:Get full text
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Summary:The aldol addition of acyldiazomethane with aromatic aldehydes, vinyl aldehyde and aliphatic aldehydes was carried out efficiently in the presence of MgI 2 etherate and iPr 2 EtN (DIPEA) using untreated reagent-grade CH 2 Cl 2 under atmospheric conditions in good to excellent yields. Iodide counterion and a non-coordinating reaction media (i.e. CH 2 Cl 2 ) are among the critical factors for the unique reactivity of this reaction system.
ISSN:0792-1241
2191-0219
DOI:10.1515/mgmc-2017-0006