Influence of exercises using different energy metabolism systems on NNMT expression in different types of skeletal muscle fibers

Nicotinamide N-methyltransferase (NNMT) plays important roles in energy metabolism and in numerous non-infectious chronic diseases (NCD). The aim of this paper is to observe the influence of the different energy metabolism types on the NNMT expression, which is helpful to understand the roles of NNM...

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Bibliographic Details
Published in:Science & sports 2017-02, Vol.32 (1), p.27-32
Main Authors: Li, J.-H., Qiu, L.-Q., Zhu, X.-J., Cai, C.-X.
Format: Article
Language:English
Subjects:
Cardio-cerebrovascular diseases
Diabetes
Diabète
Energy
Exercise
Homocysteine
Homocystéine
Maladies cardio-cérébrovasculaire
Metabolism
Methylnicotinamide
Méthylnicotinamide
Obesity
Obésité
Studies
Wellness programs
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Summary:Nicotinamide N-methyltransferase (NNMT) plays important roles in energy metabolism and in numerous non-infectious chronic diseases (NCD). The aim of this paper is to observe the influence of the different energy metabolism types on the NNMT expression, which is helpful to understand the roles of NNMT in energy metabolism and to develop exercise therapies against NCD. Thirty Sprague-Dawley rats were randomly distributed into three groups, the control group (CG), the below lactate threshold (LT) group (BLTG) and the supra lactate threshold group (SLTG), and then a 6-week run training program was performed. Before the formal training, the blood lactate of the rats was measured immediately after a 30min continuous running. Twenty-four hours after the last training session, the extensor digitorum longus muscle (EDL) and the soleus muscles were isolated for analysis of western blot. The blood lactate level of the BLTG is only slightly higher than that of the CG (P>0.05), but that of the SLTG is highly significantly higher than that of the CG or of the BLTG (P
ISSN:0765-1597
DOI:10.1016/j.scispo.2016.06.004