Fast and Convenient NIR Spectroscopy Procedure for Determination of Metformin Hydrochloride in Tablets

A rapid and convenient near-infrared (NIR) reflectance spectroscopic procedure for the determination of metformin hydrochloride in tablets is presented. Determination was based on calibration curves that were obtained using a range of standards containing different concentrations of metformin hydroc...

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Bibliographic Details
Published in:Journal of applied spectroscopy 2017-09, Vol.84 (4), p.710-715
Main Authors: Pyzowski, J., Lenartowicz, M., Sobańska, A. W., Brzezińska, E.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Atomic/Molecular Structure and Spectra
Calibration
Densitometers
Densitometry
Metformin
Near infrared radiation
Physics
Physics and Astronomy
Polyvinylpyrrolidone
Reflectance
Spectrum analysis
Tablets
Thin layer chromatography
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Summary:A rapid and convenient near-infrared (NIR) reflectance spectroscopic procedure for the determination of metformin hydrochloride in tablets is presented. Determination was based on calibration curves that were obtained using a range of standards containing different concentrations of metformin hydrochloride blended with polyvinylpyrrolidone. The raw spectra of the standards, neat PVP, metformin hydrochloride, and powdered tablets were processed using a Multiplicative Scatter Correction filter as well as by the derivative spectroscopy method to give a basis for the calibration curve construction. The results were validated by thin-layer chromatography followed by UV-densitometry.
ISSN:0021-9037
1573-8647
DOI:10.1007/s10812-017-0534-z