Isolation, characterization and anti diabetic effect 1,2,3,8,9&;tetramethoxy&;6, 6a, 7, 12&;tetrahydro;5h;12a;aza&; benzo[a] anthracene monohydrate alkaloid from the tubers of stephania glabra and its crystal structure

• Published in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2017-09, Vol.17 (4), p.S59-S59
• Main Author: Ashok Kumar, C.K.
• Format: Article
• Language: English
• Subjects: Anthracene; Antidiabetics; Crystal structure; Diabetes; Diabetes mellitus; Menispermaceae; Scaevola glabra; Tubers
• ISSN: 1424-3903; 1424-3911
• DOI: 10.1016/j.pan.2017.07.202

Aim: To isolate and characterize a chief constituent of Stephania glabra and exploration of its anti diabetic potential Method: Isolation; Column Chromatography Characterization: IR, NMR, M and x-ray crystallography Prelinical: STZ induced diabetes in rats Results: The alkaloid, (−) 2,3,8,9−Tetramethoxy−6, 6a, 7, 12−tetrahydro −5H− 12a−aza− benzo[a] anthracene monohydrate (1), C21H25NO4.H2O [ASG], showed 1460.81 cm−1 (Ar−N), 1285 cm−1 (C−N), 1050−1350 cm−1 (OCH3) and 3610 cm−1 (−OH of H2O) absorption in the IR spectrum. [...]X−ray crystallographic analysis was carried out for the single crystal obtained from pure isolated compound for gaining deeper insight of the structural features and determined the exact configuration of the said alkaloid. [...]many enzymatic estimation and free radical scavenging activities supporting the hypoglycaemic effect are to be thoroughly screened to know the exact mechanism of action for the hypoglycaemic effect of the said alkaloid, so that it can be developed into a potent hypoglycaemic agent.