[18F]-Sodium fluoride uptake in Takayasu arteritis

While 18F-fluorodeoxyglucose and 18F-sodium fluoride with positron emission tomography relate with inflammation and calcification, their role in the assessment of patients with Takayasu arteritis has not yet been studied. We present 5 patients with suspected active metabolic disease who underwent PE...

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Bibliographic Details
Published in:Journal of nuclear cardiology 2017-10, Vol.24 (5), p.1674-1679
Main Authors: Alexanderson-Rosas, E., Monroy-Gonzalez, A.G., Juarez-Orozco, Luis Eduardo, Martinez-Aguilar, M.M., Estrada, E., Soldevilla, I., Garcia-Pérez, O., Soto-Lopez, M.E.
Format: Article
Language:English
Subjects:
18F-Fluorodeoxyglucose (18F-FDG)
18F-sodium fluoride (18F-NaF)
Adult
Aorta - diagnostic imaging
Brief Report
Calcification
Calcinosis - diagnostic imaging
Cardiology
Female
Fluoridation
Fluorides
Fluorine Radioisotopes - pharmacokinetics
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Imaging
Inflammation
Male
Medicine
Medicine & Public Health
Metabolic disorders
Middle Aged
Nuclear Medicine
PET/CT imaging
Positron-Emission Tomography
Radiology
Sodium
Sodium Fluoride - pharmacokinetics
Takayasu arteritis
Takayasu Arteritis - diagnostic imaging
Vein & artery diseases
Young Adult
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Summary:While 18F-fluorodeoxyglucose and 18F-sodium fluoride with positron emission tomography relate with inflammation and calcification, their role in the assessment of patients with Takayasu arteritis has not yet been studied. We present 5 patients with suspected active metabolic disease who underwent PET with 18F-fluorodeoxyglucose and 18F-sodium fluoride in order to explore the locations and correlations of 18F-fluorodeoxyglucose and 18F-sodium fluoride uptakes. Diagnosis of metabolic active disease was based on 18F-fluorodeoxyglucose uptake. We studied 3 female patients and 2 male patients. Median age was 29 years (min: 19 max: 63). In areas with atherosclerotic plaques, we found a negative correlation between 18F-sodium fluoride and 18F-fluorodeoxyglucose uptakes (r = −0.78) (P = .001). Meanwhile, in areas with only metabolic active disease, we found a positive correlation between 18F-sodium fluoride and 18F-fluorodeoxyglucose uptakes (r = 0.94) (P = .019). In Takayasu arteritis, 18F-sodium fluoride uptake can document different stages of metabolic disease, even in the absence of active metabolic disease or symptoms.
ISSN:1071-3581
1532-6551
DOI:10.1007/s12350-016-0627-8