Fingerprint of long non-coding RNA regulated by cyclic mechanical stretch in human aortic smooth muscle cells: implications for hypertension

Emerging evidence suggests that long non-coding RNAs (lncRNAs) represent a cellular hub coordinating various cellular processes that are critical in health and disease. Mechanical stress triggers changes in vascular smooth muscle cells (VSMCs) that in turn contribute to pathophysiological changes wi...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2017-11, Vol.435 (1-2), p.163-173
Main Authors: Mantella, Laura-Eve, Singh, Krishna K., Sandhu, Paul, Kantores, Crystal, Ramadan, Azza, Khyzha, Nadiya, Quan, Adrian, Al-Omran, Mohammed, Fish, Jason E., Jankov, Robert P., Verma, Subodh
Format: Article
Language:English
Subjects:
Aberration
Analysis
Aorta
Biochemistry
Biomedical and Life Sciences
Cardiology
Cell differentiation
Cells
DNA microarrays
Elongation
Encyclopedias
External stimuli
Gene expression
Genes
Genomes
Hypertension
Life Sciences
Mechanical properties
Medical Biochemistry
Non-coding RNA
Oncology
Ribonucleic acid
RNA
Signal transduction
Smooth muscle
Switches
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Summary:Emerging evidence suggests that long non-coding RNAs (lncRNAs) represent a cellular hub coordinating various cellular processes that are critical in health and disease. Mechanical stress triggers changes in vascular smooth muscle cells (VSMCs) that in turn contribute to pathophysiological changes within the vasculature. We sought to evaluate the role that lncRNAs play in mechanical stretch-induced alterations of human aortic smooth muscle cells (HASMCs). RNA (lncRNA and mRNA) samples isolated from HASMCs that had been subjected to 10 or 20% elongation (1 Hz) for 24 h were profiled with the Arraystar Human LncRNA Microarray V3.0. LncRNA expression was quantified in parallel via qRT-PCR. Of the 30,586 human lncRNAs screened, 580 were differentially expressed (DE, P  
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-017-3065-2