Synthesis, Characterization and Pharmacological activity of colplexes of Cu(II), Ni(II), Mn(II) and Co(II) from Chalcone N(4)-methyl(phenyl)thiosemicarbazone

[...]the main objective of the present work was to prepare transition metal complexes of chalcone N(4)methyl(phenyl)thiosemicarbazone and to find out its binding mode in the complexes, the other objectives are to explore the antimicrobial properties and cytotoxicity of these complexes. The common fe...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2017-09, Vol.9 (9), p.1444
Main Authors: Verma, C Priya, Kumar, K Subin, Aravindhakshan, K K
Format: Article
Language:English
Subjects:
Antioxidants
Cancer
Chemistry
Cytotoxicity
Ethanol
Ligands
Studies
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Summary:[...]the main objective of the present work was to prepare transition metal complexes of chalcone N(4)methyl(phenyl)thiosemicarbazone and to find out its binding mode in the complexes, the other objectives are to explore the antimicrobial properties and cytotoxicity of these complexes. The common feature of compounds with the carcinostatic potency is the presence of soft donor (NS) atoms. [...]the antitumour studies carried out on chalcone N(4)-methyl(phenyl)thiosemicarbazone and its metal complexes have proven their potentiality as cytotoxic agents against EAC (Ehrlich Ascites Carcinoma) induced ascites cell lines. The higher lipophilicity is expected to enhance the antimicrobial properties as well. [...]the lipophilic cell wall with lipids and polysaccharides as some of the essential constituents, favours the passage of metal chelates into the cells. The inhibitive action of these metal chelates on the growth of the tested microorganisms is due to the presence of highly liposoluble azomethine groups as donor sites. [...]the form of inhibitive action of the complexes may involve the hydrogen bond formation through the coordinated anions and azomethine group with the active centers in the cell [23, 24].
ISSN:0975-1459