Split liver transplantation for retroperitoneal immature teratoma masquerading as hepatoblastoma

Extragonadal teratoma originating from the retroperitoneum represents less than 5% of all teratomas and accounts for less than 10% of all pediatric retroperitoneal neoplasms. To date, there has been no report of teratoma managed with LT. This study reports an infant aged 3 months with retroperitonea...

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Bibliographic Details
Published in:Pediatric transplantation 2017-11, Vol.21 (7), p.n/a
Main Authors: Oh, Dongkyu, Yi, Nam‐Joon, Song, Sanghee, Kim, Ok Kyung, Hong, Suk Kyun, Yoon, Kyung Chul, Ahn, Sung Woo, Kim, Hyo‐Sin, Kim, Hyeyoung, Kim, Hyun‐Young, Kang, Hyoung Jin, Lee, Myungsu, Lee, Kyoung Bun, Lee, Kwang‐Woong, Suh, Kyung Suk
Format: Article
Language:English
Subjects:
Biopsy
Chemotherapy
Cisplatin
Diagnosis, Differential
Doxorubicin
Hepatic artery
Hepatoblastoma - diagnosis
Humans
immature teratoma
Infant
Liver Neoplasms - diagnosis
Liver transplantation
Liver Transplantation - methods
Liver transplants
Male
Neoplasia
pediatric
Retroperitoneal Neoplasms - diagnosis
Retroperitoneal Neoplasms - surgery
Retroperitoneum
Teratoma
Teratoma - diagnosis
Teratoma - surgery
Transplantation
Vinblastine
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Summary:Extragonadal teratoma originating from the retroperitoneum represents less than 5% of all teratomas and accounts for less than 10% of all pediatric retroperitoneal neoplasms. To date, there has been no report of teratoma managed with LT. This study reports an infant aged 3 months with retroperitoneal immature teratoma involving the hepatic hilum, refractory to chemotherapy and treated with LT. The patient was referred to our hospital for management of a growing abdominal mass. Histopathology of a fine needle biopsy of the lesion suggested the possibility of a hepatoblastoma with teratoid features. Cisplatin‐based chemotherapy was initiated, but rapid growth of the tumor encasing the hepatic artery proper was detected, even after two cycles of chemotherapy. A split LT was carried out, and pathological examination of the explanted liver revealed the involvement of numerous neuroepithelial components, confirming the diagnosis of a Norris grade 3 immature teratoma. The patient recovered well and was discharged on day 19 post‐LT. As on date, on postoperative day 240, he has completed seven cycles of a 12‐cycle vinblastine and doxorubicin‐based adjuvant chemotherapy.
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.13025