CAN-catalyzed microwave promoted reaction of indole with Betti bases under solvent-free condition and evaluation of antibacterial activity of the products

CAN-catalyzed reaction of Betti bases with indoles under microwave irradiation gives 3-(α,α-diarylmethyl)indoles. Better yield of the products, especially when one of the aryl ring is phenol were achieved. The reaction is performed in solvent-free condition. The antibacterial studies of the synthesi...

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Bibliographic Details
Published in:Synthetic communications 2017-11, Vol.47 (21), p.2007-2014
Main Authors: Pegu, Choitanya Dev, Nasrin, Sheikh Benazir, Deb, Mohit L., Das, Deep Jyoti, Saikia, Kandarpa K., Baruah, Pranjal K.
Format: Article
Language:English
Subjects:
3-(α,α-diarylmethyl)indoles
Aromatic compounds
Bacteria
Betti base
CAN-catalyzed
Chemical synthesis
Indoles
microwave
solvent-free
Solvents
Staphylococcus infections
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Summary:CAN-catalyzed reaction of Betti bases with indoles under microwave irradiation gives 3-(α,α-diarylmethyl)indoles. Better yield of the products, especially when one of the aryl ring is phenol were achieved. The reaction is performed in solvent-free condition. The antibacterial studies of the synthesized compounds were performed and some of the compounds showed good activity against Methicillin-resistant Staphylococcus aureus bacteria.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2017.1360912