Formulation aspects behind the development of a stable biphasic liquid dosage form with special reference to microemulsion

• Published in: Research journal of pharmacy and technology 2017-05, Vol.10 (5), p.1509
• Main Authors: Gupta, Shriya, Dhokne, Sonali, Verma, Rameshwar, Mitra, Manish, Sahu, Umesh, Bhardwaj, Pitamber, Bhoyar, Mohainish, Biswas, Manoj, Sahu, Lukesh, Jha, Sheetal, Agrawal, Mukta, Tripathi, D. K., Ajazuddin, Alexander, Amit
• Format: Article
• Language: English
• Subjects: Bioavailability; Cosmetics; Drug delivery systems; Drug dosages; Equilibrium; Microemulsions; Pharmaceuticals; Researchers; Surfactants; Toxicity
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2017.00266.9

[...]they mismatching with solvent by micellization process the dispersed phase typically comprises of small particle droplets with a size range of 5nm to 100nm, and has very low oil/water interfacial tension because the droplet size is less than 25% of the wavelength of the visual light, microemulsion are transparent.. [...]due to their water content, microemulsions cannot be encapsulated in soft gelatin or hard gelatin capsules LIMITATIONS 171 There are certain factors which limits the use of the microemulsion systems in the pharmaceutical applications: [...]a micro pH meter is used to check the pH of the different samples. Since the pH of the formulation is the factor upon which the microemulsion stability and the bioavailability of the drug through microemulsion at the permeation site depends upon. Since formation of microemulsion formation requires high surfactant concentration, the skin irritation aspect must be considered especially when they are intended to be applied for a longer period. * Ophthalmic delivery In conventional ophthalmic dosage forms, water soluble drugs are delivered in aqueous solution while water insoluble drugs are formulated as suspension or ointments.