Clinical biochemistry profile of biventricular heart failure in a mixed-breed bitch

A six-year old mixed-breed bitch was presented for chronic ascites. A diagnostic work-up was crafted to ascertain the cause of fluid accumulation in the peritoneal cavity. Clinical biochemistry tests for status of the liver and kidneys were performed. Elevations in absolute concentrations of the liv...

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Bibliographic Details
Published in:Comparative clinical pathology 2017-11, Vol.26 (6), p.1407-1411
Main Authors: Musara, Colin, Tivapasi, Musavenga T.
Format: Article
Language:English
Subjects:
Albumin
Alkaline phosphatase
Ascites
Aspartate aminotransferase
Bilirubin
Biochemistry
Case Report
Creatinine
Heart diseases
Heart failure
Hematology
Liver
Medicine
Medicine & Public Health
Oncology
Pathology
Peritoneum
Renal failure
Renal function
Urea
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Summary:A six-year old mixed-breed bitch was presented for chronic ascites. A diagnostic work-up was crafted to ascertain the cause of fluid accumulation in the peritoneal cavity. Clinical biochemistry tests for status of the liver and kidneys were performed. Elevations in absolute concentrations of the liver enzymes aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were useful in evaluation of hepatocellular damage associated with right-sided heart failure. Normal levels of serum albumin and bilirubin, however, underscored the preserved functional capacity of the liver in spite of hepatocellular damage. Elevation of blood urea nitrogen, but not creatinine, was significant in appraisal of low cardiac output chronic renal failure resulting from left-sided heart failure. Increase in blood urea nitrogen was a valuable prognostic indicator of subsequent death resulting from biventricular heart failure, in contrast to serum bilirubin or albumin concentrations. Clinical biochemical profiles for liver and kidney functions in heart failure patients allow for estimation of the extent of hepatic and renal complications. Renal dysfunction carries a grave prognosis.
ISSN:1618-5641
1618-565X
DOI:10.1007/s00580-017-2562-8