The effect of three bufadienolide cardiac glycosides on contraction of isolated rat jejunum

Three cardiac glycosides were screened for pharmacological effects on isolated rat jejunum. The contraction of rat jejunum with epoxyscillirosidin, a non-cumulative bufadienolide, and cotyledoside and tyledoside D, both cumulative neurotoxic bufadienolides were compared with methacholine. The result...

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Bibliographic Details
Published in:Onderstepoort journal of veterinary research 2002-09, Vol.69 (3), p.243
Main Authors: Botha, C.J, Gehring, R. (Pretoria Univ., Onderstepoort (South Africa). Paraclinical Sciences Dept.), Van Rooyen, J.M, Venter, D
Format: Article
Language:English
Subjects:
AFRIQUE DU SUD
Animals
Atropine - pharmacology
BETAIL
Bufanolides - pharmacology
Cardiac Glycosides - pharmacology
CARDIOVASCULAR AGENTS
Cholenes - pharmacology
Dose-Response Relationship, Drug
ENVENENAMIENTO
Enzyme Inhibitors - pharmacology
FARMACOLOGIA
Female
GANADO
In Vitro Techniques
INTESTIN
INTESTINES
INTESTINOS
INTOXICATION
Jejunum - drug effects
LIVESTOCK
Male
MEDICAMENTOS CARDIOVASCULARES
Methacholine Chloride - pharmacology
MODIFICATEUR CARDIOVASCULAIRE
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
PHARMACOLOGIE
PHARMACOLOGY
POISONING
RAT
RATA
RATS
Rats, Sprague-Dawley
SOUTH AFRICA
SUDAFRICA
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Summary:Three cardiac glycosides were screened for pharmacological effects on isolated rat jejunum. The contraction of rat jejunum with epoxyscillirosidin, a non-cumulative bufadienolide, and cotyledoside and tyledoside D, both cumulative neurotoxic bufadienolides were compared with methacholine. The results indicate that all three bufadienolides cause contraction of jejunal smooth muscle. When combined with atropine (1 x 10(-6) M) the response of epoxyscillirosidin and tyledoside D decreased, indicating suppression of a cholinergic response caused by the cardiac glycosides.
ISSN:0030-2465
2219-0635