Anti-inflammatory/infection PLA nanoparticles labeled with technetium 99m for in vivo imaging

Despite advancements in treatment of infectious diseases, opportunistic pathogens continue to pose a worldwide threat. Identifying a source of infection/inflammation is often challenging which highlights the need of improved diagnostic agents. Using a model of local S. aureus infection, here we eval...

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Bibliographic Details
Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2017-10, Vol.19 (10), p.1-8, Article 345
Main Authors: dos Santos, Sofia Nascimento, dos Reis, Sara Rhaissa Rezende, Pinto, Suyene Rocha, Cerqueira-Coutinho, Cristal, Nigro, Fiammetta, Barja-Fidalgo, Thereza Christina, Pinheiro, Nathalia Martins Alexandre, Neto, Heitor Affonso Paula, Santos-Oliveira, Ralph
Format: Article
Language:English
Subjects:
Brief Communication
Characterization and Evaluation of Materials
Chemistry and Materials Science
Dexamethasone
Diagnostic agents
Diagnostic systems
Infections
Infectious diseases
Inflammation
Inorganic Chemistry
Lasers
Materials Science
Nanoparticles
Nanotechnology
Opportunist infection
Optical Devices
Optics
Photonics
Physical Chemistry
Polylactic acid
Steroids
Technetium
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Summary:Despite advancements in treatment of infectious diseases, opportunistic pathogens continue to pose a worldwide threat. Identifying a source of infection/inflammation is often challenging which highlights the need of improved diagnostic agents. Using a model of local S. aureus infection, here we evaluated the potential of betamethasone or dexamethasone loaded in poly (lactic acid) nanoparticles and radiolabeled with 99mTc to detect an infection/inflammation site in vivo. A betamethasone and dexamethasone nanoparticles (NPs) with 200 and 220 nm in size, respectively, were created with a 98% 99mTc radiolabeling efficiency. When injected in infected mice, betamethasone NPs presented a higher accumulation in the infected hind paw in comparison with dexamethasone NPs. Our results suggest that this nanosystem may be a valid nanoradiopharmaceutical for the detection of inflammation/infection foci in vivo. Graphical abstract Nanoradiopharmaceutical for inflammation
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-017-4037-x