GW28-e0939 Discovery of dynamical network biomarkers (DNB) during the progression of atherosclerosis using multiple omic techniques and systems biology

Methods Combining omics data and theoretical analysis to establish a theoretical model for early prediction of the dysregulation of blood vessel homeostasis and atherosclerotic lesion formation from the viewpoint of systems biology. [...]we integrated high throughput data including different-stage d...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2017-10, Vol.70 (16), p.C34-C35
Main Authors: Ge, Jing, Fan, Xiaoya, Xue, Xinli, Li, Gaopeng, Zhong, Shanshan, Shen, Xia, Yin, Huiyong, Chen, Luonan
Format: Article
Language:English
Subjects:
Arteriosclerosis
Atherosclerosis
Biomarkers
Cardiology
Oxidation
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Summary:Methods Combining omics data and theoretical analysis to establish a theoretical model for early prediction of the dysregulation of blood vessel homeostasis and atherosclerotic lesion formation from the viewpoint of systems biology. [...]we integrated high throughput data including different-stage data of RNA-seq and metabolomics/lipidomics to discover regulatory networks of atherosclerosis and identify dynamical network biomarkers (DNB) to characterize the critical transition from normal vessel to atherosclerotic lesion.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.07.119