Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium

The aim of this study was to compare plasma and serum protein profiles in elderly acute hip fracture patients with and without delirium. The spectra from surface-enhanced laser desorption ionization (SELDI) using time-of-flight (TOF) mass spectrometry of 16 patients without and 16 patients with deli...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2009-07, Vol.21 (3), p.284-291
Main Authors: van Munster, Barbara C, van Breemen, Marielle J, Moerland, Perry D, Speijer, Dave, De Rooij, Sophia E, Pfrommer, Christel J, Levi, Marcel, Hollmann, Markus W, Aerts, Johannes M, Zwinderman, Aeilko H, Korevaar, Johanna C
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Aged, 80 and over
Biological and medical sciences
Delirium - blood
Delirium - diagnosis
Delirium - metabolism
Female
Hemoglobins - metabolism
Hip Fractures - blood
Hip Fractures - metabolism
Humans
Male
Mass Spectrometry
Medical sciences
Organic mental disorders. Neuropsychology
Protein Array Analysis
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Time Factors
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Summary:The aim of this study was to compare plasma and serum protein profiles in elderly acute hip fracture patients with and without delirium. The spectra from surface-enhanced laser desorption ionization (SELDI) using time-of-flight (TOF) mass spectrometry of 16 patients without and 16 patients with delirium (two groups of eight and eight) scored using the Confusion Assessment Method were compared. The most discriminating peak of 15.9 kDa in plasma in a testing group of eight patients with delirium to eight patients without delirium was confirmed in an independent validation group. Taking both groups together, three discriminating peaks of 7.97, 15.9, and 16.0 kDa were found in delirious patients. These peaks presumably correspond to hemoglobin-beta, its doubly charged ion, and its glycosylated form.
ISSN:0895-0172
1545-7222
DOI:10.1176/jnp.2009.21.3.284