Emergent Complications Following Donepezil Switchover to Galantamine in Three Cases of Dementia With Lewy Bodies

Delayed disease progression and symptomatic improvement occur with cholinesterase inhibitors (ChEIs) in dementia with Lewy bodies (DLB). In this study, complications (insomnia, dyskinesias, agitation, and delirium) occurred in three patients switched from donepezil to galantamine. The authors descri...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2005, Vol.17 (4), p.552-555
Main Authors: Bhanji, Nadeem H, Gauthier, Serge
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cholinesterase Inhibitors - therapeutic use
Disease Progression
Galantamine - adverse effects
Humans
Indans - therapeutic use
Lewy Body Disease - drug therapy
Male
Medical sciences
Mental Status Schedule
Neuropharmacology
Neuropsychological Tests
Pharmacology. Drug treatments
Piperidines - therapeutic use
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
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Summary:Delayed disease progression and symptomatic improvement occur with cholinesterase inhibitors (ChEIs) in dementia with Lewy bodies (DLB). In this study, complications (insomnia, dyskinesias, agitation, and delirium) occurred in three patients switched from donepezil to galantamine. The authors describe evidence-based recommendations for ChEI switchover in DLB.
ISSN:0895-0172
1545-7222
DOI:10.1176/jnp.17.4.552