An MRI Study of the Corpus Callosum and Cerebellum in Mentally Retarded Autistic Individuals

The areas of seven subregions of the corpus callosum and three subregions of the cerebellum were examined on midsagittal magnetic resonance imaging scans of 27 low-IQ autistic individuals and 17 nonautistic individuals of comparable mental age. Autistic individuals had a significantly smaller corpus...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 1999-11, Vol.11 (4), p.470-474
Main Authors: Manes, Facundo, Piven, Joseph, Vrancic, Daniela, Nanclares, Valeria, Plebst, Christian, Starkstein, Sergio E
Format: Article
Language:English
Subjects:
Adolescent
Autistic Disorder
Cerebellum - pathology
Corpus Callosum - pathology
Female
Humans
Intellectual Disability
Magnetic Resonance Imaging
Male
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Summary:The areas of seven subregions of the corpus callosum and three subregions of the cerebellum were examined on midsagittal magnetic resonance imaging scans of 27 low-IQ autistic individuals and 17 nonautistic individuals of comparable mental age. Autistic individuals had a significantly smaller corpus callosum (most marked in the body). No significant between-group differences were found in cerebellum areas. Results demonstrate that abnormalities of the corpus callosum reported in high-functioning autistic individuals are also present in autistic individuals with mental retardation and extend previous reports showing no evidence for a selective hypoplasia of cerebellar lobules VI-VII.
ISSN:0895-0172
1545-7222
DOI:10.1176/jnp.11.4.470