One-pot three-component green synthesis of novel dihydrophthalazine-1,4-diones

Green and efficient one-pot three-component synthesis of novel 2-(7-amino-2,2-dimethyl-4-oxo-5-phenyl-4,5-dihydropyrano[2,3- d ][1,3]dioxin-6-ylcarbonyl)-2,3-dihydrophthalazine-1,4-diones have been developed by condensing 3-(1,4-dioxo-1,2,3,4-tetrahydrophthalazin-2-yl)-3-oxopropanenitrile with benza...

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Bibliographic Details
Published in:Russian journal of general chemistry 2017-09, Vol.87 (9), p.2039-2044
Main Authors: Suman, M., Vijayabhaskar, B., Syam Kumar, U. K., Venkateswara Rao, B.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Column chromatography
Dioxins
Ethanol
Proline
Synthesis
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Summary:Green and efficient one-pot three-component synthesis of novel 2-(7-amino-2,2-dimethyl-4-oxo-5-phenyl-4,5-dihydropyrano[2,3- d ][1,3]dioxin-6-ylcarbonyl)-2,3-dihydrophthalazine-1,4-diones have been developed by condensing 3-(1,4-dioxo-1,2,3,4-tetrahydrophthalazin-2-yl)-3-oxopropanenitrile with benzaldehydes and Meldrum’s acid using L-proline as catalyst in ethanol at room temperature. The products have been isolated as pure compounds in good yields without using column chromatography.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363217090201