Quetiapine (Seroquel) in the Treatment of Psychosis in Patients With Parkinson's Disease

Psychoses are a common clinical problem in patients with Parkinson's disease. Treatment with typical neuroleptics or withdrawal of antiparkinsonian drugs may improve mental symptoms but will worsen the parkinsonism. Quetiapine (Seroquel), ICI 204,636, is a novel antipsychotic medication with a...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 1998, Vol.10 (2), p.216-219
Main Authors: Parsa, Mahmoud A, Bastani, Bijan
Format: Article
Language:English
Subjects:
Aged
Antipsychotic Agents - adverse effects
Antipsychotic Agents - therapeutic use
Dibenzothiazepines - therapeutic use
Dyskinesia, Drug-Induced - prevention & control
Female
Humans
Male
Parkinson Disease - complications
Psychosis
Psychotic Disorders - complications
Psychotic Disorders - drug therapy
Quetiapine Fumarate
Severity of Illness Index
Treatment Outcome
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Summary:Psychoses are a common clinical problem in patients with Parkinson's disease. Treatment with typical neuroleptics or withdrawal of antiparkinsonian drugs may improve mental symptoms but will worsen the parkinsonism. Quetiapine (Seroquel), ICI 204,636, is a novel antipsychotic medication with a low potential for producing extrapyramidal side effects. In this open-label clinical study of 2 patients with Parkinson's disease, treatment with Seroquel successfully controlled psychotic symptoms without worsening of motor disability.
ISSN:0895-0172
1545-7222
DOI:10.1176/jnp.10.2.216