Synthesis, characterization, DNA binding and cleavage activity of homoleptic zinc(II) [beta]-oxodithioester chelate complexes

New homoleptic zinc(II) complexes, [Zn(L)2], where L = methyl-3-hydroxy-(3-pyridyl)-2-propenedithioate L1 1, and methyl-3-hydroxy-(4-pyridyl)-2-propenedithioate L2 2, have been synthesized and characterized by elemental (C, H, and N) analysis, ESI-MS, and (IR, UV-vis, NMR) spectroscopy; the structur...

Full description

Saved in:
Bibliographic Details
Published in:Journal of coordination chemistry 2017-09, Vol.70 (18), p.3171
Main Authors: Yadav, Manoj Kumar, Maurya, Akhilendra Kumar, Rajput, Gunjan, Manar, Krishna Kumar, Vinayak, Manjula, Drew, Michael G B, Singh, Nanhai
Format: Article
Language:English
Subjects:
Anticancer properties
Ascorbic acid
Binding
Breast cancer
Cancer
Cleavage
Coordination compounds
Crystallography
Deoxyribonucleic acid
DNA
Hydrogen peroxide
Infrared radiation
Nitrogen
NMR
Nuclear magnetic resonance
Toxicity
Zinc
Zinc compounds
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:New homoleptic zinc(II) complexes, [Zn(L)2], where L = methyl-3-hydroxy-(3-pyridyl)-2-propenedithioate L1 1, and methyl-3-hydroxy-(4-pyridyl)-2-propenedithioate L2 2, have been synthesized and characterized by elemental (C, H, and N) analysis, ESI-MS, and (IR, UV-vis, NMR) spectroscopy; the structure of 1 has been deduced by X-ray crystallography. The DNA binding and cleavage activity of the complexes have been studied. The cleavage potential of pBR322 DNA by 1 and 2 has been checked. Complex 1, which contains nitrogen of the pyridine group in the 3-position enhances DNA cleavage potential in the presence of ascorbic acid; however, the complex is protective against DNA cleavage in the presence of DMSO or H2O2. Also, 1 causes cytotoxicity against the MCF-7 breast cancer cell line. The efficient cytotoxic activity and DNA cleavage ability of 1 in the presence of ascorbic acid shows its potential anticancer properties and the need for further investigations of its potential as an anticancer drug.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2017.1377835