Mesoporous Silica Nanoparticles: Membrane Fusion Mediated Intracellular Delivery of Lipid Bilayer Coated Mesoporous Silica Nanoparticles (Adv. Healthcare Mater. 20/2017)

In article number 1700759, Alexander Kros and co‐workers describe how mesoporous silica nanoparticles (MSNs) are delivered into cells via membrane fusion thereby omitting endocytosis pathways. Fusion is induced by a pair of complementary coiled‐coil lipopeptides inserted into the membrane of cells a...

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Bibliographic Details
Published in:Advanced healthcare materials 2017-10, Vol.6 (20), p.n/a
Main Authors: Yang, Jian, Tu, Jing, Lamers, Gerda E. M., Olsthoorn, René C. L., Kros, Alexander
Format: Article
Language:English
Subjects:
Cytoplasm
Endocytosis
intracellular delivery
lipid bilayers
Lipopeptides
Membrane fusion
mesoporous silica nanoparticles
Nanoparticles
Porous materials
Proteins
Silica
Silicon dioxide
Workers
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Description
Summary:In article number 1700759, Alexander Kros and co‐workers describe how mesoporous silica nanoparticles (MSNs) are delivered into cells via membrane fusion thereby omitting endocytosis pathways. Fusion is induced by a pair of complementary coiled‐coil lipopeptides inserted into the membrane of cells and in the bilayer of lipid‐coated MSNs. In this manner proteins can be efficiently delivered into the cytoplasm of cells.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201770104