Synthesis and characterization of acrylamide-based copolymeric hydrogel-silver composites: Antimicrobial activities and inhibition kinetics against E. coli

A series of acrylamide (AAm)-based hydrogels containing acrylic acid, 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), and vinyl imidazole (VI) comonomers were prepared by free radical polymerization. Silver nanoparticles were loaded to hydrogel systems through in situ reduction of silver nitrat...

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Bibliographic Details
Published in:International journal of polymeric materials 2017-12, Vol.66 (18), p.934-942
Main Authors: Boztepe, Cihangir, Tosun, Emir, Bilenler, Tugca, Sislioglu, Kubra
Format: Article
Language:English
Subjects:
Acrylamide
Acrylamide-based hydrogels
Acrylic acid
Agar
Antiinfectives and antibacterials
antimicrobial activity
Antimicrobial agents
Chemical synthesis
Cobalt
Dilution
E coli
Free radical polymerization
hydrogel-silver composites
Hydrogels
Imidazole
inhibition kinetic
Microorganisms
Particulate composites
Silver
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Summary:A series of acrylamide (AAm)-based hydrogels containing acrylic acid, 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), and vinyl imidazole (VI) comonomers were prepared by free radical polymerization. Silver nanoparticles were loaded to hydrogel systems through in situ reduction of silver nitrate in the presence of sodium borohydride as a reducing agent. The synthesized hydrogels and their composites were characterized using FTIR, scanning electron microscopy, EDX, and EDX-mapping. The antimicrobial activity of hydrogel-silver composite was determined using well agar and broth dilution tests. In the first stage, four different hydrogel-silver composites were evaluated against six different microorganisms using the well agar technique. The most effective hydrogel-silver composite among all tested was poly(AAm-co-VI-co-AMPS)-Ag, while the most sensitive and resistant microorganisms among all tested were Staphylococcus cerevisiae and S. aureus, respectively. Poly(AAm-co-VI-co-AMPS)-Ag composite was used in modeling the inhibition kinetic of Escherichia coli. The present study displays that hydrogel-silver composite has considerable antimicrobial activity, which deserves further investigation for use in clinic application and industrial processing.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2017.1291513