Delayed language development due to infantile thiamine deficiency

The aim of this study was to investigate the language development of 20 children who had been exposed to thiamine (vitamin B1) deficiency in infancy due to feeding with soy‐based formula that was accidentally deficient of thiamine. In this case–control study, 20 children (12 males, eight females; me...

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Published in:Developmental medicine and child neurology 2009-08, Vol.51 (8), p.629-634
Main Authors: FATTAL‐VALEVSKI, AVIVA, AZOURI‐FATTAL, IRIS, GREENSTEIN, YORAM J, GUINDY, MICHAL, BLAU, AYALA, ZELNIK, NATHANEL
Format: Article
Language:English
Subjects:
Alcoholism
Case-Control Studies
Child Development - physiology
Child, Preschool
Cognitive Development
Control Groups
Expressive Language
Female
Females
Follow-Up Studies
Humans
Infant
Infant Formula - chemistry
Infants
Israel
Language Acquisition
Language Development Disorders - chemically induced
Language Development Disorders - diagnosis
Language Development Disorders - epidemiology
Listening Comprehension
Male
Males
Motor Activity - physiology
Motor Development
Physical Activities
Preschool children
Receptive Language
Soy Milk - chemistry
Thiamine - analysis
Thiamine Deficiency - etiology
Thiamine Deficiency - physiopathology
Thiamine Deficiency - psychology
Young Children
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Summary:The aim of this study was to investigate the language development of 20 children who had been exposed to thiamine (vitamin B1) deficiency in infancy due to feeding with soy‐based formula that was accidentally deficient of thiamine. In this case–control study, 20 children (12 males, eight females; mean age 31.8mo [SD 4.1], range 24–39mo) who were fed thiamine‐deficient formula in infancy were compared with 20 children (12 males, eight females; mean age 32.2mo [SD 3.9], range 25–39mo) fed with other milk sources and matched for age, sex, and maternal education. Receptive and expressive language development was assessed with the Preschool Language Scale, 3rd edition. Other assessments included mental development (Bayley Scales of Infant Development, 2nd edition), evaluation for autistic spectrum disorders, and neurological examination. Motor development was compared by age at independent walking. The study and control groups differed significantly in the expressive communication (p
ISSN:0012-1622
1469-8749
DOI:10.1111/j.1469-8749.2008.03161.x