Long-term toxicity of immune suppression in juvenile rheumatic diseases

Although there are not many studies which have addressed long-term outcomes in children with rheumatic disease treated with immunosuppressive agents, the data that are available, as well as information from adult studies, suggest significant long-term concerns with all the agents that have demonstra...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 1999-08, Vol.38 (8), p.743-746
Main Author: LAXER, R. M
Format: Article
Language:English
Subjects:
Adolescent
Adrenal Cortex Hormones - adverse effects
Alkylating Agents - adverse effects
Antirheumatic Agents - adverse effects
Biological and medical sciences
Child
Drug toxicity and drugs side effects treatment
Humans
Immunosuppression - adverse effects
Immunosuppressive Agents - adverse effects
Medical sciences
Methotrexate - adverse effects
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Rheumatic Diseases - therapy
Time
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Description
Summary:Although there are not many studies which have addressed long-term outcomes in children with rheumatic disease treated with immunosuppressive agents, the data that are available, as well as information from adult studies, suggest significant long-term concerns with all the agents that have demonstrable efficacy. This must lead us to investigate new methods of treatment which will not only be more effective, but also less toxic.
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/38.8.743