In vivo intra- and inter-individual variability study of human stratum corneum by confocal Raman spectroscopy

The present research work deals with the in vivo determination of intra- and inter-individual human stratum corneum biochemical variability using confocal Raman spectroscopy. This study was carried out at three different spots on the volar forearm region of healthy human participants in the extended...

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Bibliographic Details
Published in:Vibrational spectroscopy 2016-11, Vol.87, p.199-206
Main Authors: dos Santos, Laurita, Rangel, Joao Lucas, Tippavajhala, Vamshi Krishna, da Silva, Michely Glenda Pereira, Mogilevych, Borys, Martin, Airton Abrahão
Format: Article
Language:English
Subjects:
Confocal Raman spectroscopy
Correlation analysis
Correlation coefficients
Forearm
In vivo human skin variability
In vivo methods and tests
Intra- and inter-individual variability
Raman spectra
Raman spectroscopy
Skin
Spectrum analysis
Spots
Studies
Wavelengths
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Summary:The present research work deals with the in vivo determination of intra- and inter-individual human stratum corneum biochemical variability using confocal Raman spectroscopy. This study was carried out at three different spots on the volar forearm region of healthy human participants in the extended fingerprint and high wavenumber spectral regions. All the preprocessed spectra were compared by correlation matrices, which were calculated using Pearson's correlation coefficient (r). The results indicate that the participated volunteers in this study are homogenous with respect to the stratum corneum in the forearm region in both extended fingerprint and high wavenumber regions as there is high correlation between their Raman spectra at both intra- and inter-individual levels. This study confirms the application of confocal Raman spectroscopy as an accurate and precise technique for in vivo studies involving human skin.
ISSN:0924-2031
1873-3697
DOI:10.1016/j.vibspec.2016.10.007