Effect of eugenol on animal models of nociception

Objective: To investigate the antinociceptive potential of eugenol on different pain models in mice. Materials and Methods : Eugenol was evaluated (1-100 mg/kg, i.p.) in various experimentally induced pain models like, formalin induced hyperalgesia, acetic acid induced abdominal constrictions, and t...

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Bibliographic Details
Published in:Indian journal of pharmacology 2006-09, Vol.38 (5), p.341
Main Author: Kurian R, Arulmozhi DK, Veeranjaneyulu A, Bodhankar SL
Format: Article
Language:English
Subjects:
Antinociceptive, clove oil, pain models
Care and treatment
Eugenol
Health aspects
Pain
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Summary:Objective: To investigate the antinociceptive potential of eugenol on different pain models in mice. Materials and Methods : Eugenol was evaluated (1-100 mg/kg, i.p.) in various experimentally induced pain models like, formalin induced hyperalgesia, acetic acid induced abdominal constrictions, and thermal pain experiment using Eddy's hot plate. Results : Eugenol significantly inhibited acetic acid induced abdominal constrictions, with the maximal effect (92.73% inhibition) at 100 mg/kg. In formalin induced paw licking pain model, eugenol exhibited more pronounced antinociceptive effect in the inflammatory phase than the neurogenic phase (maximal effect was 70.33% and 42.22%, respectively, at 100 mg/kg, i.p). A mild reduction in the pain response latency at 100 mg/kg, i.p. dose of eugenol was observed in the hotplate thermal pain studies in mice. In the rotarod motor coordination experiment eugenol reduced the endurance time at the dose of 100 mg/kg, i.p. Conclusion: The data suggest that eugenol exerts antinociceptive activity in different experimental models of pain in mice.
ISSN:0253-7613
1998-3751
DOI:10.4103/0253-7613.27702