Buyanghuanwu decoction inhibited TLR4-induced activation of nuclear factor-kappa B in acute carbon monoxide poisoning rats

Acute carbon monoxide poisoning (ACMP) is one of the most common types of poisoning worldwide, and may result in delayed encephalopathy, however, its pathogenesis remains obscure and there is no optimal treatment strategy for the patients with ACMP. Here, we developed the ACMP rat model to observe t...

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Bibliographic Details
Published in:PeerJ preprints 2015-07
Main Authors: Li, Weirong, Wang, Xiuwei, Guan, Zhen, Zheng, Yufei, Zhang, Xiaodong, Shi, Jing, Niu, Bo
Format: Article
Language:English
Subjects:
Carbon monoxide
Carbon monoxide poisoning
Encephalopathy
Hippocampus
Inflammation
MyD88 protein
Neuroprotection
NF-κB protein
Poisoning
Rodents
TLR4 protein
Toll-like receptors
Tumor necrosis factor
Tumor necrosis factor-α
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Summary:Acute carbon monoxide poisoning (ACMP) is one of the most common types of poisoning worldwide, and may result in delayed encephalopathy, however, its pathogenesis remains obscure and there is no optimal treatment strategy for the patients with ACMP. Here, we developed the ACMP rat model to observe the protective effects of Buyanghuanwu decoction (BYHWD) on hippocampal neuron. BYHWD (per 5 g/kg) were intragastric administration to rats twice each day for 28 days after ACMP. In ACMP + BYHWD group rats, the neuronal injury in the hippocampal region was significantly less than that of ACMP group’s. BYHWD of intragastric administration also markedly decreased the expression of the TLR4, MyD88, NF-κB P65 after acute carbon monoxide poisoning (P
ISSN:2167-9843
DOI:10.7287/peerj.preprints.1226v1