Vasoactive properties of antihypertensive lactoferrin-derived peptides in resistance vessels: Effects in small mesenteric arteries from SHR rats

Bovine lactoferrin (LF) hydrolysates and peptides identified thereof have shown antihypertensive effects in rat models, mainly but not exclusively by angiotensin-converting enzyme inhibition. In this study we aimed to assess the vasoactive effects and mechanisms of an ultrafiltered (

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Bibliographic Details
Published in:Life sciences (1973) 2017-10, Vol.186, p.118-124
Main Authors: García-Tejedor, Aurora, Manzanares, Paloma, Castelló-Ruiz, María, Moscardó, Antonio, Marcos, José F., Salom, Juan B.
Format: Article
Language:English
Subjects:
Acetylcholine
Action mechanism
Angiotensin
Animal models
Animals
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - chemistry
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Antihypertensive effects
Antihypertensives
Arteries
Blood Pressure - drug effects
Blood vessels
Chlorides
Dose-Response Relationship, Drug
Efflux
Endothelium
Hydrolysates
Hypertension - drug therapy
Hypertension - physiopathology
In Vitro Techniques
Indomethacin
Inhibitors
Isometric
Lactoferrin
Lactoferrin - chemistry
Lactoferrin-derived peptides
Male
Mesenteric Arteries - drug effects
Mesenteric Arteries - physiopathology
Mesenteric artery
NG-Nitroarginine methyl ester
Nitric-oxide synthase
Oligopeptides - administration & dosage
Oligopeptides - chemistry
Oligopeptides - pharmacology
Oligopeptides - therapeutic use
Pepsin
Peptides
Peptidyl-dipeptidase A
Phenylephrine
Potassium chloride
Prostaglandin endoperoxide synthase
Prostaglandins
Protein Hydrolysates - administration & dosage
Protein Hydrolysates - chemistry
Protein Hydrolysates - pharmacology
Protein Hydrolysates - therapeutic use
Proteolysis
Rats
Rats, Inbred SHR
Rodents
Sodium
Sodium nitroprusside
Spontaneously hypertensive rat
Vascular Resistance - drug effects
Vasoactive agents
Vasodilation - drug effects
Vasorelaxation
Veins & arteries
Yeast
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Description
Summary:Bovine lactoferrin (LF) hydrolysates and peptides identified thereof have shown antihypertensive effects in rat models, mainly but not exclusively by angiotensin-converting enzyme inhibition. In this study we aimed to assess the vasoactive effects and mechanisms of an ultrafiltered (
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2017.07.036