Modified-Nutrition Index is a Significant Prognostic Factor for the Overall Survival of the Nasopharyngeal Carcinoma Patients who Undergo Intensity-modulated Radiotherapy

Purpose: To explore whether the modified-nutrition index (m-NI) is a prognostic factor for the overall survival (OS) in nasopharyngeal carcinoma (NPC) patients who undergo intensity-modulated radiotherapy (IMRT). Methods: Clinical data were prospectively collected from NPC patients who underwent IMR...

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Bibliographic Details
Published in:Nutrition and cancer 2017-10, Vol.69 (7), p.1011-1018
Main Authors: Hong, Jin-Sheng, Hua, Yang-Jing-Ling, Su, Li, Zhang, Hai-Rong, Lv, Wen-Long, Chen, Xiu-Ying, Tian, Jun, Zhang, Wei-Jian
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Albumin
Arm
Body mass
Body Mass Index
Body size
Carcinoma - drug therapy
Carcinoma - mortality
Carcinoma - radiotherapy
Cell number
Erythrocytes
Female
Females
Hemoglobin
Humans
Kaplan-Meier Estimate
Male
Males
Malnutrition
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - drug therapy
Nasopharyngeal Neoplasms - mortality
Nasopharyngeal Neoplasms - radiotherapy
Nutrition
Nutrition Assessment
Nutritional status
Nutritional Status - physiology
Patients
Prognosis
Prospective Studies
Radiation therapy
Radiotherapy, Intensity-Modulated
Regression analysis
Survival
Survival Rate
Throat cancer
Transferrin
Transferrins
Young Adult
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Summary:Purpose: To explore whether the modified-nutrition index (m-NI) is a prognostic factor for the overall survival (OS) in nasopharyngeal carcinoma (NPC) patients who undergo intensity-modulated radiotherapy (IMRT). Methods: Clinical data were prospectively collected from NPC patients who underwent IMRT at our hospital between October 2008 and December 2014. The patient nutritional status before radiotherapy was evaluated using the m-NI, based on eight nutrition indicators including body mass index, arm muscle circumference, albumin, total lymphocyte count, red blood cell count, hemoglobin, serum pre-albumin, and transferrin. The independent prognostic value of m-NI for the OS was evaluated. Results: A total of 323 patients (229 males, 94 females) were included in this study, and the follow-up rate was 99.7% (322/323). The 1-, 3-, and 5-yr OS rates between malnutrition and normal nutrition groups by using the m-NI were 93.0% vs. 96.9%, 76.4% vs. 82.8%, and 61.8% vs. 77.1%, respectively. A regression analysis showed that the m-NI was the significant prognostic value for the OS in NPC. Conclusions: The m-NI before radiotherapy is a significant prognostic factor for the OS in NPC patients. Further validation of our instrument is needed in other NPC patients.
ISSN:0163-5581
1532-7914
DOI:10.1080/01635581.2017.1359311