Radiosynthesis and biodistribution of 99mTc-Sulfamethoxazole: a novel molecule for in-vivo infection imaging

The aim of this study was to prepare 99m Tc-Sulfamethoxazole complex and evaluate its efficiency as an infection imaging agent. The Sulfamethoxazole was labeled with 99m Tc and its biological efficacy as a potential radio tracer for Staphylococcus aureus infection was investigated in bacterially inf...

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Published in:Medicinal chemistry research 2017, Vol.26 (12), p.3149-3157
Main Authors: Uyaroğlu, Özge, Demiroğlu, Hasan, Topal, Gökçen, Parlak, Yasemin, Gül Gümüşer, Fikriye, Uluer Türköz, Elgin, Demir, Volkan, Ateş, Buket, Ünak, Perihan, Avcıbaşı, Uğur
Format: Article
Language:English
Subjects:
Bacteria
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Imaging
Infections
Original Research
Pharmaceuticals
Pharmacology/Toxicology
Radiochemistry
Radioisotopes
Rats
Rodents
Sulfamethoxazole
Technetium isotopes
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Summary:The aim of this study was to prepare 99m Tc-Sulfamethoxazole complex and evaluate its efficiency as an infection imaging agent. The Sulfamethoxazole was labeled with 99m Tc and its biological efficacy as a potential radio tracer for Staphylococcus aureus infection was investigated in bacterially infected Albino Wistar rats. The radiolabeling yield was found to be 95 ± 3.07% and remained constant at more than 93 ± 0.1% even in serum for 240 min after radiolabeling. 99m Tc-Sulfamethoxazole prepared with high yield localized well in the bacterially infected muscle of the rats. 99m Tc-Sulfamethoxazole may be developed as a radiopharmaceutical agent to distinguish infection from inflammation by nuclear imaging.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-017-2009-4