Comparison of the percentages of CD4+ￂ CD25highￂ FOXP3+, CD4+ￂ CD25lowￂ FOXP3+, and CD4+ￂ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia

Problem Little is known about how preeclampsia affects regulatory T-cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2017-12, Vol.78 (6)
Main Authors: El-Chennawi, Farha, Rageh, Ibrahim Mohamed, Mansour, Amira Ibrahim, Darwish, Mohammed Ibrahim, Elghzaly, Ashraf Antar, Sakr, Basma El Sayed, Elbaz, Khaled Mohsen
Format: Article
Language:English
Subjects:
CD25 antigen
CD4 antigen
Cord blood
Flow cytometry
Foxp3 protein
Lymphocytes T
Pre-eclampsia
Preeclampsia
Sons
Umbilical cord
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Summary:Problem Little is known about how preeclampsia affects regulatory T-cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia. Method of study The percentage of umbilical cord blood CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs were analyzed by flow cytometry. Results CD4+ CD25high FOXP3+ Treg (%) and CD4+ FOXP3+ Treg (%) were significantly lower, while CD4+ CD25low (%) was significantly higher in umbilical cord blood of babies born to preeclamptic mothers. Conclusion Preeclampsia is associated with immune dysregulation which leads to a deficiency in Treg (CD4+ CD25high FOXP3+) in the umbilical cord blood of babies born to preeclamptic mothers.
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.12761