Frontispiece: Biosynthesis and Total Synthesis of Pyrronazol B: a Secondary Metabolite from Nannocystis pusilla

Both the biosynthesis as well as the chemical synthesis of pyrronazol follow a modular approach starting with a pyrrole building block. This secondary metabolite was isolated from Nannocystis pusilla Ari7 and both routes utilize modular extensions to introduce an oxazole moiety and to generate the u...

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Bibliographic Details
Published in:Chemistry : a European journal 2017-11, Vol.23 (63), p.n/a
Main Authors: Witte, Swjatoslaw N. R., Hug, Joachim J., Géraldy, Magalie N. E., Müller, Rolf, Kalesse, Markus
Format: Article
Language:English
Subjects:
Biosynthesis
biosynthetic gene cluster
Chemical synthesis
Chemistry
deprotection
Oxazole
pyrronazol
total synthesis
Online Access:Get full text
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Summary:Both the biosynthesis as well as the chemical synthesis of pyrronazol follow a modular approach starting with a pyrrole building block. This secondary metabolite was isolated from Nannocystis pusilla Ari7 and both routes utilize modular extensions to introduce an oxazole moiety and to generate the unsaturated lactone through ester condensation steps. For more information see the Full Paper by M. Kalesse et al. on page 15917 ff.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201786364