A new cinnamic acid glycoside from roots of Heracleum dissectum

From the roots of Heracleum dissectum Lebb., one new cinnamic acid glycoside derivative named dissectumoside (1), together with eight known compounds including three phenolics, three phenolic glycosides and two phenylpropanoic glycoside were isolated using various chromatographic methods. Among them...

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Bibliographic Details
Published in:Natural product research 2018-01, Vol.32 (2), p.133-140
Main Authors: Wang, Zhi-Gang, Mi, Jie, Wang, Xin-Rui, Huo, Ya-Yu, Peng, Ya-Jie, Zhang, Hai-Min, Gao, Yang, Zhang, Hai-Long
Format: Article
Language:English
Subjects:
3T3-L1 adipocytes
3T3-L1 Cells
Adipocytes
Adipocytes - drug effects
Adipogenesis
Adipogenesis - drug effects
Animals
Cardiac Glycosides
Chromatography
Cinnamates - chemistry
Cinnamates - isolation & purification
Cinnamic acid
cinnamic acid glycoside
edible Oroqen herb
Glycosides
Glycosides - chemistry
Glycosides - isolation & purification
Heracleum
Heracleum - chemistry
Heracleum dissectum
Magnetic resonance spectroscopy
Mass spectrometry
Mass spectroscopy
Mice
NMR
NMR spectroscopy
Nuclear magnetic resonance
Phenolic compounds
Phenols
Phenols - chemistry
Physicochemical properties
Plant Extracts - chemistry
Plant Roots - chemistry
Roots
triglycerides accumulation
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Summary:From the roots of Heracleum dissectum Lebb., one new cinnamic acid glycoside derivative named dissectumoside (1), together with eight known compounds including three phenolics, three phenolic glycosides and two phenylpropanoic glycoside were isolated using various chromatographic methods. Among them compound 2-9 was isolated from the plant for the first time. Their structures were elucidated and identified on the basis of their physicochemical properties and by extensive analyses of NMR spectroscopy and high-resolution mass spectrometry. The results of triglyceride accumulation screening in 3T3-L1 cells showed that compounds 1, 5 and 9 exhibited significantly accelerating activities of adipogenesis in adipocytes.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2017.1340285