Collision of lymphoepithelioma‐like carcinoma and adenocarcinoma of the lung: a case report

We report a rare case of collision of lymphoepithelioma‐like carcinoma (LELC) and adenocarcinoma (AC) in the lung. A 59‐year‐old woman had a history of fever and cough. A mass was found by X‐ray in the left upper lung. Magnetic resonance imaging (MRI) shows a dumbbell‐like mass in the fore and tongu...

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Bibliographic Details
Published in:The clinical respiratory journal 2017-11, Vol.11 (6), p.1052-1056
Main Authors: Chan, Jammy Kin Iong, Tai, Wai Meng, Wen, Jian Ming
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
adenocarcinoma – collision carcinoma – lung – lymphoepithelioma‐like carcinoma
Biomarkers, Tumor
Case reports
Epstein-Barr Virus Infections
Female
Fluorodeoxyglucose F18
Humans
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Lymph Nodes - pathology
Lymphatic system
Magnetic Resonance Imaging - methods
Middle Aged
Neoplasms, Squamous Cell - drug therapy
Neoplasms, Squamous Cell - metabolism
Neoplasms, Squamous Cell - pathology
Neoplasms, Squamous Cell - surgery
NMR
Nuclear magnetic resonance
Positron Emission Tomography Computed Tomography - methods
Tomography
Tomography, X-Ray Computed - methods
Treatment Outcome
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Summary:We report a rare case of collision of lymphoepithelioma‐like carcinoma (LELC) and adenocarcinoma (AC) in the lung. A 59‐year‐old woman had a history of fever and cough. A mass was found by X‐ray in the left upper lung. Magnetic resonance imaging (MRI) shows a dumbbell‐like mass in the fore and tongue segment of the left upper lung with irregular spiculate margin. Positron emission tomography/computed tomography (PET/CT) (18F‐FDG) shows strong concentration of radioactivity (SUVmax 6.9–12.3 cm) in the lung mass only. The patient subsequently underwent resection of left upper lung and associated hilar lymph nodes. Histological examination revealed it was a collision carcinoma comprising LELC and AC. The hilar lymph nodes were tumuor free. The immunoreactions, Epstein–Barr early RNA in situ hybridization and molecular analyses, such as EGFR mutation, c‐Met, anaplastic lymphoma kinase were different in both tumuor components, indicating they derived from different cell origin. This rare case was discussed.
ISSN:1752-6981
1752-699X
DOI:10.1111/crj.12404