Multifunctional polyHIPE wound dressings for the treatment of severe limb trauma

Trauma suffered in combat is frequently of greater severity than that faced in the civilian sector and access to advanced care is often limited. Therefore, multifunctional wound dressings, capable of high absorption, hemostatic activity and antimicrobial drug delivery, are of significant interest in...

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Bibliographic Details
Published in:Polymer (Guilford) 2017-09, Vol.126, p.408-418
Main Authors: McGann, Christopher L., Streifel, Benjamin C., Lundin, Jeffrey G., Wynne, James H.
Format: Article
Language:English
Subjects:
Absorption
Absorptivity
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Biocompatibility
Biological materials
Biological properties
Biomaterial
Calcium
Clotting
Cytocompatibility
Drug delivery
Drug delivery systems
Drug therapy
Emulsions
Foams
Hemostasis
High internal phase emulsion
Hydrogel
Medical dressings
Plastic foam
Polyacrylate
Polyelectrolyte
Polyethylene glycol
Sodium
Trauma
Wound dressing
Wound healing
Wounds
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Summary:Trauma suffered in combat is frequently of greater severity than that faced in the civilian sector and access to advanced care is often limited. Therefore, multifunctional wound dressings, capable of high absorption, hemostatic activity and antimicrobial drug delivery, are of significant interest in improving point-of-injury care. Here, polymeric foams composed of poly(ethylene glycol) diacrylate, sodium/calcium polyacrylate and PNIPAM, were synthesized via high internal phase emulsion (HIPE) templating and demonstrated exceptional material properties and biological performance for application as wound dressing materials. The polyHIPE foams exhibited typical HIPE hierarchical microstructure, a high capacity for fluid absorption and excellent cytocompatibility. Furthermore, the materials were highly effective at clotting whole blood and capable of loading/delivering active antibiotics. Porous polymeric foams prepared via high internal phase emulsions (HIPEs) offer an exciting method for the rational design of wound dressing materials that are highly absorptive, hemostatic and capable of antimicrobial drug delivery. [Display omitted] •High internal phase emulsion (HIPE) templating was utilized to form cross-linked polyelectrolyte polymer foams with hierarchical porosity.•The foams exhibited high fluid uptake when immersed in aqueous buffer and were found to have excellent cytocompatibility.•PolyHIPE foams demonstrated improved clotting efficacy over untreated rayon gauze and were capable of delivering active antibiotics under physiological relevant conditions.
ISSN:0032-3861
1873-2291
DOI:10.1016/j.polymer.2017.05.067