Synthesis of Novel Pyrazole Derivatives as Antineoplastic Agent

Anticancer evaluation of pyrazole 2 and Schiff base 5 is reported. Synthesis of some important heterocyclic compounds via 2,3‐diaryloxirane‐2,3‐dicarbonitrile 1, pyrazole 2, and Schiff base 5 with different nitrogen nucleophiles afforded new routes for synthesized fused heterocyclic derivatives. The...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2017-11, Vol.54 (6), p.3358-3371
Main Authors: Rizk, Sameh A., El‐Sayed, Amira A., Mounier, Marwa M.
Format: Article
Language:English
Subjects:
Anticancer properties
Aromatic compounds
Cancer
Chemical synthesis
Derivatives
Heterocyclic compounds
Imines
Nitrogen
Nitrogen compounds
Nucleophiles
Pyrazole
Reagents
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Summary:Anticancer evaluation of pyrazole 2 and Schiff base 5 is reported. Synthesis of some important heterocyclic compounds via 2,3‐diaryloxirane‐2,3‐dicarbonitrile 1, pyrazole 2, and Schiff base 5 with different nitrogen nucleophiles afforded new routes for synthesized fused heterocyclic derivatives. These compounds can be used as a key starting materials to synthesize some important imidazolo‐[4,5‐c]pyrazole, pyrazolo[3,4‐e]1,2,4‐triaging, imidazolo[3,2‐b]pyrazole, and pyrazolo‐pyrazine, as anticancer reagents showed good results at optimum conditions (400–500 ppm), particularly the bridge head nitrogen compounds, and could be used to improve them. Electromeric effect of the halogen atom in the aryl moieties can be controlled upon the rate of reaction and the yield of the product. The structure of the synthesized new compounds would be characterized by elemental and spectral data.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2956