Synthesis and Antioxidant Activity of a New Class of Pyridinylcarbamoylmethyl Pyrrolyl/Pyrazolylcarboxamides

A new class of pyridinylcarbamoylmethyl pyrrolyl/pyrazolylcarboxamides was prepared from the synthetic intermediate pyridinylcarbamoylmethyl cinnamamide adopting simple and versatile synthetic methodologies. All the synthesized compounds were evaluated for antioxidant activity. Among all the tested...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2017-11, Vol.54 (6), p.3498-3509
Main Authors: Gudi, Yamini, Gundala, Sravya, Venkatapuram, Padmavathi, Adivireddy, Padmaja, Chippada, Appa Rao, Allagadda, Rajasekhar
Format: Article
Language:English
Subjects:
Antioxidants
Ascorbic acid
Pyridines
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Summary:A new class of pyridinylcarbamoylmethyl pyrrolyl/pyrazolylcarboxamides was prepared from the synthetic intermediate pyridinylcarbamoylmethyl cinnamamide adopting simple and versatile synthetic methodologies. All the synthesized compounds were evaluated for antioxidant activity. Among all the tested compounds, the methoxy‐substituted pyrazolyl pyridines displayed significant antioxidant activity in all the three methods when compared with the standard ascorbic acid. Moreover, compounds having more number of electron‐donating groups exhibited greater activity.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2973