Plants of Brazilian restingas with tripanocide activity against Trypanosoma cruzi strains

Chagas disease is caused by the Trypanosoma cruzi affecting millions of people, and widespread throughout Latin America. This disease exhibits a problematic chemotherapy. Benznidazole, which is the drug currently used as standard treatment, lamentably evokes several adverse reactions. Among other op...

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Published in:Journal of bioenergetics and biomembranes 2017-12, Vol.49 (6), p.473-483
Main Authors: Faria, Robson Xavier, Souza, André Luis Almeida, Lima, Barbara, Tietbohl, Luis Armando Candido, Fernandes, Caio Pinho, Amaral, Raquel Rodrigues, Ruppelt, Bettina Monika, Santos, Marcelo Guerra, Rocha, Leandro
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Language:English
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Summary:Chagas disease is caused by the Trypanosoma cruzi affecting millions of people, and widespread throughout Latin America. This disease exhibits a problematic chemotherapy. Benznidazole, which is the drug currently used as standard treatment, lamentably evokes several adverse reactions. Among other options, natural products have been tested to discover a novel therapeutic drug for this disease. A lot of plants from the Brazilian flora did not contain studies about their biological effects. Restinga de Jurubatiba from Brazil is a sandbank ecosystem poorly studied in relation to plant biological activity. Thus, three plant species from Restinga de Jurubatiba were tested against in vitro antiprotozoal activity. Among six extracts obtained from leaves and stem parts and 2 essential oils derived from leave parts, only 3 extracts inhibited epimastigote proliferation. Substances present in the extracts with activity were isolated (quercetin, myricetin, and ursolic acid), and evaluated in relation to antiprotozoal activity against epimastigote Y and Dm28 Trypanosoma cruzi strains. All isolated substances were effective to reduce protozoal proliferation. Essentially, quercetin and myricetin did not cause mammalian cell toxicity. In summary, myricetin and quercetin molecule can be used as a scaffold to develop new effective drugs against Chagas’s disease.
ISSN:0145-479X
1573-6881
DOI:10.1007/s10863-017-9733-9