Supramolecular hydrogels with multi-cylindrical lamellar bilayers: Swelling-induced contraction and anisotropic molecular diffusion

Novel, supramolecular, anisotropic hydrogels (called MC-PDGI gels) are presented in this study. These MC-PDGI gels consist of multi-cylindrical lipid bilayers aligned in a uniaxial manner and embedded in a soft hydrogel matrix. The bilayers and the hydrogel interact weakly due to hydrogen bonding. T...

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Bibliographic Details
Published in:Polymer (Guilford) 2017-10, Vol.128, p.373-378
Main Authors: Mito, Kei, Haque, Md. Anamul, Nakajima, Tasuku, Uchiumi, Maki, Kurokawa, Takayuki, Nonoyama, Takayuki, Gong, Jian Ping
Format: Article
Language:English
Subjects:
Anisotropy
Bilayer
Bonding strength
Chemical bonds
Contraction
Diffusion
Drug delivery systems
Elasticity
Gel
Gels
Hydrogels
Hydrogen
Hydrogen bonding
Lipid bilayers
Molecular diffusion
Multilayers
Surface tension
Swelling
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Summary:Novel, supramolecular, anisotropic hydrogels (called MC-PDGI gels) are presented in this study. These MC-PDGI gels consist of multi-cylindrical lipid bilayers aligned in a uniaxial manner and embedded in a soft hydrogel matrix. The bilayers and the hydrogel interact weakly due to hydrogen bonding. These MC-PDGI gels swell after exposure to water, which causes their volume and diameter to increase while simultaneously causing their length to decrease. This anisotropic swelling-induced contraction behavior is the result of competition between the isotropic elasticity of the hydrogel matrix and the interfacial tension of the lipid bilayers. Moreover, the MC-PDGI gels exhibit unique quasi one-dimensional diffusion behavior owing to the difficulty of molecular penetration through the multi-layered lipid bilayers. These materials would be useful for prolonged drug release or as an actuator. [Display omitted] •Supramolecular MC-PDGI gels consisting of multi-cylindrical lipid bilayers embedded in a soft hydrogel matrix have been created.•The lipid bilayers in the MC-PDGI gels are aligned in a uniaxial manner due to strong shearing.•The MC-PDGI gels show swelling-induced contraction behavior.•Quasi 1-dimensional molecular diffusion has been observed in the anisotropic MC-PDGI gels.
ISSN:0032-3861
1873-2291
DOI:10.1016/j.polymer.2017.01.038